Determinants of Plasma Retinol and Beta-Carotene Levels Summary: Observational studies have suggested that low dietary intake or low plasma concentrations of retinol, beta-carotene, or other carotenoids might be associated with increased risk of developing certain types of cancer. However, relatively few studies have investigated the determinants of plasma concentrations of these micronutrients. We designed a cross-sectional study to investigate the relationship between personal characteristics and dietary factors, and plasma concentrations of retinol, beta-carotene and other carotenoids. Study subjects (N = 315) were patients who had an elective surgical procedure during a three-year period to biopsy or remove a lesion of the lung, colon, breast, skin, ovary or uterus that was found to be non-cancerous. We display the data for only two of the analytes. Plasma concentrations of the micronutrients varied widely from subject to subject. While plasma retinol levels varied by age and sex, the only dietary predictor was alcohol consumption (R^2 = .38). Plasma beta-carotene levels were log-transformed prior to the analyses due to severe asymmetry of the residuals on the original scale. For log beta-carotene, dietary intake, regular use of vitamins, and intake of fiber were associated with higher plasma concentrations, while Quetelet Index (defined as weight/height^2 in the units kg/m^2) and cholesterol intake were associated with lower plasma levels, adjusting for the other factors (R^2 = .50). There was one extremely high leverage point in alcohol consumption that was deleted prior to the analyses. Plasma concentrations of retinol and beta-carotene were not correlated. We conclude that there is wide variability in plasma concentrations of these micronutrients in humans, and that much of this variability is associated with dietary habits and personal characteristics. A better understanding of the physiological relationship between some personal characteristics and plasma concentrations of these micronutrients will require further study. Authorization: Contact Authors Reference: These data have not been published yet but a related reference is Nierenberg DW, Stukel TA, Baron JA, Dain BJ, Greenberg ER. Determinants of plasma levels of beta-carotene and retinol. American Journal of Epidemiology 1989;130:511-521. Description: This datafile contains 315 observations on 14 variables. This data set can be used to demonstrate multiple regression, transformations, categorical variables, outliers, pooled tests of significance and model building strategies. Variable Names in order from left to right: AGE: Age (years) SEX: Sex (1=Male, 2=Female). SMOKSTAT: Smoking status (1=Never, 2=Former, 3=Current Smoker) QUETELET: Quetelet (weight/(height^2)) VITUSE: Vitamin Use (1=Yes, fairly often, 2=Yes, not often, 3=No) CALORIES: Number of calories consumed per day. FAT: Grams of fat consumed per day. FIBER: Grams of fiber consumed per day. ALCOHOL: Number of alcoholic drinks consumed per week. CHOLESTEROL: Cholesterol consumed (mg per day). BETADIET: Dietary beta-carotene consumed (mcg per day). RETDIET: Dietary retinol consumed (mcg per day) BETAPLASMA: Plasma beta-carotene (ng/ml) RETPLASMA: Plasma Retinol (ng/ml) 64 2 2 21.4838 1 1298.8 57 6.3 0 170.3 1945 890 200 915 76 2 1 23.87631 1 1032.5 50.1 15.8 0 75.8 2653 451 124 727 38 2 2 20.0108 2 2372.3 83.6 19.1 14.1 257.9 6321 660 328 721 40 2 2 25.14062 3 2449.5 97.5 26.5 0.5 332.6 1061 864 153 615 72 2 1 20.98504 1 1952.1 82.6 16.2 0 170.8 2863 1209 92 799 40 2 2 27.52136 3 1366.9 56 9.6 1.3 154.6 1729 1439 148 654 65 2 1 22.01154 2 2213.9 52 28.7 0 255.1 5371 802 258 834 58 2 1 28.75702 1 1595.6 63.4 10.9 0 214.1 823 2571 64 825 35 2 1 23.07662 3 1800.5 57.8 20.3 0.6 233.6 2895 944 218 517 55 2 2 34.96995 3 1263.6 39.6 15.5 0 171.9 3307 493 81 562 66 2 2 20.94647 1 1460.8 58 18.2 1 137.4 1714 535 184 935 40 2 1 36.43161 2 1638.2 49.3 14.9 0 130.7 2031 492 91 741 57 1 1 31.73039 3 2072.9 106.7 9.6 0.9 420 1982 1105 120 679 66 2 1 21.78854 1 987.5 35.6 10.3 0 254.9 2120 1047 61 507 66 1 1 27.31916 3 1574.3 75 7.1 0 361.5 1388 980 108 852 64 1 2 31.44674 3 2868.5 128.8 15 20 379.5 3888 1545 211 1249 62 1 2 25.90246 1 1751.1 80.7 8.4 14.1 160.3 2194 242 235 1035 75 1 2 29.15264 1 1407.6 35 20.8 7 144.1 3470 479 288 1262 68 2 1 38.18727 3 1628.5 78.6 11.6 0 512.3 2108 921 102 904 57 1 2 25.89669 3 1101.4 48.5 8.5 5 197.2 1157 445 113 1727 56 1 2 24.45884 3 2433.6 127.6 19.9 7.1 271.2 1739 926 74 684 30 2 2 22.72121 3 1437.3 61.5 8.8 2.3 160.9 1008 695 129 537 34 2 1 24.08119 3 2062.7 81.1 13.6 18 190.5 606 944 140 760 53 2 2 23.15985 2 1276.5 50.1 9 4.7 143.5 1380 708 138 809 60 2 1 49.12033 1 2114.8 77.6 14.9 0.5 239.9 4916 1150 143 697 50 2 1 23.07662 1 1113 32.8 12.9 3 104.8 4451 554 416 676 62 2 2 33.72441 2 1323 60.8 11.4 0 155.8 5983 320 212 822 61 2 1 25.18267 1 2837.3 84.2 33.8 0 192.1 2413 656 786 691 65 1 1 28.94981 3 2055.9 111.8 15.9 0 226.5 3087 1199 35 599 71 1 2 24.67999 3 1285.8 55.4 10.6 2 353.4 521 975 122 901 43 2 2 28.40151 3 1786.9 93.9 10.6 0 247 2431 914 119 818 33 2 2 20.5696 2 3144.8 155 17.6 4.1 308.8 3141 1579 182 623 74 2 3 16.33114 3 1241 53.1 10.8 0.1 206.1 1668 1618 186 624 41 2 1 21.03125 3 2419.3 122.7 16.2 0.3 325.2 4366 1759 216 526 56 1 2 22.64384 2 2712.7 145.3 13.4 8 242.6 494 608 751 1002 44 2 3 25.87867 1 1810 95.3 17.5 0 253.1 7026 508 39 179 37 2 2 35.36012 2 1778.1 75.9 10.8 0.5 332.6 1529 517 107 564 37 2 2 25.94005 3 1147.9 47.6 7.3 0.1 117 241 314 74 456 39 1 3 21.99912 1 1951.4 109.1 4.7 0 461.1 998 588 418 665 37 2 1 22.51215 1 2035.5 65.7 22.1 0.7 205.3 6082 674 1415 632 53 2 1 27.49272 3 1248.6 56.9 8.2 0 223.2 2741 419 400 502 66 2 2 27.49609 3 3184.8 199 16.8 0.2 362.6 2100 1083 102 838 58 2 2 24.17971 2 1538.1 78.7 14.2 0.9 231.2 2359 834 135 574 31 2 3 23.34593 2 1456.5 56.6 8.5 1 182.7 603 473 97 611 49 2 1 21.67837 2 1656.3 59.5 13.3 0.1 180.3 1625 707 124 476 75 2 1 21.32906 1 1396.8 53.3 13.2 3.2 99.3 2888 323 195 546 62 2 1 33.74417 1 1588.1 88.9 7.4 0 362.6 1099 651 107 411 56 2 1 32.07484 3 1566.5 95.2 6.5 7.2 408 2103 855 53 475 69 1 2 31.66835 1 827.9 32.8 8.7 0 79.8 2260 264 148 321 50 2 3 25.11194 3 2340.4 110.4 11.3 14 260.7 452 550 77 388 50 2 1 20.40345 3 1902.9 72.9 35.4 7.3 175.6 3549 969 316 586 72 2 1 39.22295 1 1111.9 47.2 10.2 0.2 69.4 2204 239 77 648 60 2 1 19.9326 2 1333.8 37.1 16.9 6.5 84 4964 374 266 550 55 1 2 21.63617 3 1896.1 82.2 9.3 10 296.8 1052 605 39 783 43 2 1 29.00466 1 1472.7 61.8 12.2 0 216.3 3572 809 225 258 29 2 1 18.83396 1 2237.4 77.6 22.6 0.7 180.6 2902 1065 173 299 44 2 3 29.11351 2 1446.2 63.2 9.5 3.2 208.8 1788 677 79 384 48 2 2 32.34834 1 2908.5 139.1 16.4 0.2 511.6 5111 1359 102 692 38 2 1 23.85727 2 2190.7 96.9 17.7 1.3 192.1 1378 685 158 634 33 2 1 19.409 2 1878.2 81.6 9.6 4.9 265.8 1431 724 159 592 56 2 1 16.63666 1 1436.8 57.2 9.4 0 183.3 1727 898 157 383 65 1 3 23.37617 3 6662.2 164.3 11.3 203 603 2893 1364 96 317 48 2 1 30.29495 1 2893.3 125.8 18.8 1.7 256.7 2524 1250 160 247 66 1 2 22.57426 1 1902.4 76.7 17.7 3.1 216.7 2533 592 100 730 78 2 2 26.36754 1 1531.6 69.5 5.4 0 168 982 854 293 587 65 1 1 23.54244 3 1220.7 34.6 16.5 5.6 152.8 1535 493 171 407 72 2 2 22.01188 3 1247.7 46.8 10.2 0 347.9 326 407 89 831 31 2 3 21.07775 2 1631.5 75.2 8.5 0.7 277.1 1487 1120 109 531 74 2 2 25.7393 3 818.1 34.3 6.6 3.7 55.4 1114 453 129 560 61 2 1 25.18267 3 1570.1 58.7 19.3 2 158.3 1080 724 87 397 83 2 1 25.20677 2 1331.2 50.6 7.7 0.3 380.7 2492 1310 328 768 46 2 2 30.70965 2 2052.4 120.4 10.2 0 195.2 1349 860 298 393 62 2 2 23.92168 1 1823 80.3 17.4 6.2 256.8 6948 417 379 810 56 2 3 20.64102 3 1743.8 85.3 13.2 7.2 349.6 1086 464 204 624 33 1 1 26.63693 1 3457.2 166 17.5 10.5 452.8 2629 1470 75 227 45 2 2 22.36111 3 1126.7 20.4 12.5 7.2 71.8 1307 178 127 525 41 2 2 23.09389 1 3258.3 101.2 26.2 0.5 341.7 1306 1163 131 542 73 1 2 24.67999 3 2833.7 119.9 14.6 18.2 365 3465 743 21 558 31 2 2 21.33144 2 2264.3 105.5 13.4 3.2 396.5 1846 760 233 504 50 1 1 25.11989 1 2026 85.5 11.2 21 268.2 1334 486 73 1031 65 2 1 28.40199 3 1747.6 83.6 10.9 0 244.8 4848 1005 25 187 35 2 3 21.83403 1 1575.5 53.9 7 1 216.2 1734 1215 137 677 42 1 2 29.03568 1 1785.4 94.1 10 0.7 288 1120 619 82 783 19 2 1 29.24145 1 2558.9 116.1 12.3 0 324.5 1498 1066 327 693 37 2 1 19.98613 1 839 29.2 4.7 6.4 66.5 330 394 142 511 44 2 2 24.08119 1 2391.3 95.4 20.6 0 283.3 5909 1702 86 435 36 2 2 23.34593 3 1887.4 110.2 6 0.1 211.7 3326 928 150 362 53 1 3 25.14062 3 2798.2 125.9 17.7 7 239 2110 1458 53 592 69 1 3 27.22886 3 2654.9 126 23.3 0 248 2719 1323 112 360 74 2 1 27.98617 1 1202 46.6 11.4 0 59.2 2309 578 104 476 70 2 1 22.53312 1 1235.9 51.1 9.6 3 142 1153 1048 170 369 56 2 2 26.3173 3 2225.1 111.5 10.4 6.8 283.7 1432 1006 150 619 77 2 1 27.79046 1 866.9 31 9.8 0.2 59.7 2493 640 282 472 73 1 2 24.41719 1 1666.8 76.5 13.3 0 747.5 3054 4041 91 426 43 2 2 23.0381 1 3711 202.7 14.9 18 469.2 1861 783 125 592 41 1 1 23.61695 2 1055 33.2 12.9 0.9 220 4268 341 282 426 22 2 2 27.00534 1 2733 123.8 5.1 0.3 440.3 1652 1525 16 799 44 2 2 23.46046 1 1660.1 80.3 13.6 0.1 89 1802 233 129 497 51 2 2 25.1571 3 1952.7 63.8 17.9 11 201.3 2308 1838 180 622 46 1 3 35.25969 3 2667.5 131.6 10.1 0 550.5 1210 1291 39 549 25 2 3 20.64102 1 1517.4 59.1 5.9 0 127.6 214 914 54 539 69 1 2 23.00561 2 1711.4 98.2 10.8 0.3 332.4 1370 695 78 522 69 1 2 25.23171 3 1756.4 82.3 8.8 0 500.3 2354 842 34 551 58 2 1 27.33692 2 2186.2 99.3 14.9 0.2 263.8 2446 881 95 466 77 1 1 25.88131 2 2075.2 75.6 21.4 0 228.8 3473 1326 174 423 67 1 2 24.73525 3 2021.2 94.8 13.3 8 417.6 3359 1060 95 797 37 2 2 29.32557 2 1653.2 77.3 12.5 1 162.6 1062 1070 97 532 47 2 2 21.1882 2 1076.6 33.4 22.5 4.1 138.8 1489 490 204 422 60 2 3 19.67728 3 1506.7 76.3 14.6 0 239.2 3982 350 25 421 49 2 2 25.06996 2 1511.7 54.4 16.1 4.2 200.5 1656 652 270 527 83 1 2 25.59772 1 1933.6 98.8 11.1 0 224.7 768 719 285 512 56 2 1 22.01188 1 1830 52.8 13.8 8.5 689.4 1496 546 110 756 39 2 1 30.29128 3 1256.7 43.7 5.3 0.3 133.6 683 627 162 456 41 2 1 41.85592 2 1823.7 54.7 14.6 0 188 885 687 179 456 37 2 3 28.3357 3 1902.8 81.7 8.2 0 178.6 1662 779 131 449 66 2 1 26.50808 3 958.5 37.7 8.3 0 108.6 1552 326 86 406 55 2 1 21.07775 2 2328.3 112.6 13.9 2.9 281.9 2144 815 225 519 49 2 2 39.46498 1 1574 74.6 14.1 0 440.6 3567 963 249 464 31 2 2 18.98362 1 1646.2 52.2 13.2 5 174.9 1423 1845 254 523 64 2 1 18.87834 1 1828 63.4 14.7 0 87.9 1293 1101 189 588 57 2 1 23.22115 1 1288.7 63.2 10.6 0 200.2 2111 950 108 564 42 2 3 26.84912 1 1084.3 25.2 21.8 1 105.7 2874 159 121 927 40 1 2 25.88131 1 2431.9 93.7 17.8 0.1 364.6 1699 2263 238 953 73 1 3 19.409 3 2453.5 118.5 10.3 0 516.5 954 1328 127 516 37 2 1 19.57075 2 1645.7 76 6.6 4 225.9 1368 427 141 669 43 2 1 20.297 3 2075.9 96.5 17.3 7 271.8 3318 651 427 572 66 2 1 26.42051 2 1563.7 73.3 12 1.1 300.9 2247 728 305 727 26 2 1 20.37946 3 1663.3 64.6 7.6 2 124.7 910 605 74 544 45 2 2 29.24145 1 1601.4 93.9 8.8 0 255.8 1171 453 156 917 74 2 1 30.29495 2 1718.9 57.9 15 1.2 272.7 2077 1374 168 586 49 2 1 21.47901 3 1010.6 29.4 9.1 6.2 98.8 1210 555 116 516 41 2 2 19.409 1 1372.7 61.6 9.5 0 182.5 1826 386 290 404 74 1 1 27.31916 3 1837 76.9 13.6 0 383.6 2628 966 304 709 38 2 3 21.84508 3 1662.7 58.7 15.7 3.7 163.7 561 947 198 429 83 1 1 22.22237 1 1534.7 54.9 26.3 0 77.5 1893 426 253 629 70 2 1 28.04696 1 2005.8 89.5 8.5 0.1 121.2 1312 688 148 1139 39 2 2 26.09433 2 1187.8 32.8 11.6 0 154.9 1913 1048 492 466 65 2 1 21.58515 1 1446.2 56.8 10.8 0 127.9 924 684 156 372 72 2 2 21.03125 1 976.7 68.4 3.1 0 99.6 728 797 27 558 46 1 2 23.67727 3 2706.7 104.9 16.8 22 416 4387 926 52 476 46 2 1 30.05871 3 1546 73.6 10.3 7 284.8 1976 417 210 418 51 2 1 34.18512 3 1324 46 12.7 0 151 2422 208 83 564 39 2 1 24.08119 1 1368.9 61.6 14.4 6.7 314.9 1407 1335 182 431 33 2 3 20.16133 3 3228 141.1 14.4 0 718.8 1301 307 40 485 49 1 2 31.72627 3 2825.8 97.8 7.5 35 374.3 1112 735 69 733 44 2 1 23.39316 3 1220.9 35.1 14 0 99.2 1052 441 172 402 69 2 1 24.26126 3 1174.7 47.4 9.9 0.1 89.9 1008 783 253 760 52 2 2 27.83348 3 828.2 52.3 6.1 1.2 141.1 1054 366 435 659 82 2 1 20.21771 1 1708.1 94.2 15.1 2 224.7 1484 790 429 599 46 2 1 23.47858 3 1182.9 60.2 5.2 0.2 164.5 657 441 326 495 25 2 1 22.70512 2 928.4 29.7 6 0.5 120.7 604 432 75 436 54 2 1 37.86868 1 4373.6 235.9 22.9 0.1 814.7 2912 2104 121 416 70 2 1 25.7393 2 1387.7 55.2 11.2 0 114 869 1595 292 701 35 2 1 18.43855 2 1555.6 72.8 11.5 0 174.1 1578 689 207 553 46 2 1 33.19482 2 1581.7 64.1 12.3 0.1 170.1 1210 795 118 652 70 1 1 29.59659 3 1397.4 60.5 9.2 0 228.5 1554 675 108 621 71 2 2 22.15318 1 1305.4 43.3 10.2 0 72.7 3445 1015 385 617 59 2 1 26.88677 1 1249.6 24.2 14.7 0 97.2 3014 1340 408 784 42 2 1 20.5412 1 2347.3 104.4 12.5 0 249.3 1666 859 97 352 46 2 1 39.40624 3 1207.1 42.8 11.6 0 155.1 1462 868 118 677 37 2 2 33.37234 1 1688.1 45 17.1 0.8 141.1 1272 145 60 520 39 2 2 21.94091 2 1719.3 49.7 18.4 11 164.6 5296 554 357 474 43 2 2 25.58279 1 2501.6 121.1 19.5 0 343 5605 858 858 643 23 2 1 20.12592 1 2219.1 120.9 13.1 2 415.8 2430 746 104 400 45 2 2 20.23978 1 1827.7 71.2 10.4 2 267.5 2375 1284 219 627 63 2 1 23.92168 1 1282.3 26.4 13.6 0.1 100.6 3753 649 296 701 44 2 3 28.34863 2 1427.2 60.6 8.3 0.2 195 695 270 164 566 43 2 1 20.40345 1 2000.8 86.7 14.8 0.9 200.9 1649 751 487 453 33 2 2 27.86945 3 1622.4 71.5 12.9 1 214.8 2317 437 70 428 35 2 2 34.08181 3 3114 160.2 14.9 0.2 432.3 1702 1224 43 434 50 2 1 23.07159 3 2012 112.9 14.3 6.5 456.9 1007 6901 274 592 50 2 2 29.01566 2 2106.4 97 12.9 0 344.3 2308 982 231 413 59 2 2 25.59772 1 1546.6 72.9 15.1 0.7 192.8 4694 864 346 849 38 2 2 23.07662 3 1149 43.6 8.6 10.5 122.5 2749 329 181 727 60 2 2 29.74753 3 659.3 22.2 7 0.1 102 1497 244 116 700 54 2 2 19.17702 1 1580.6 82.9 9.4 5.2 98.3 1171 465 391 499 71 1 2 24.46343 3 1850.5 75.9 16.1 7.2 247.9 3054 629 85 853 48 2 2 22.53187 1 1242.1 37.5 13.3 1 148.4 1488 706 800 532 49 2 1 32.01772 1 1099.4 56.9 5.2 0.5 169.9 829 887 286 561 27 2 3 29.24145 3 1127.6 59.4 7.4 0 183.4 1037 239 87 378 27 2 3 25.44536 2 2919.5 125.3 14.3 1 370 846 2118 74 419 75 2 1 21.52782 1 1049.1 51.7 8 0 188.9 1382 222 460 694 45 2 1 26.42051 2 1366.6 42.5 12.9 2.5 141.2 3407 532 154 437 35 2 1 30.44551 3 1884.8 91.6 11.1 5 518 758 454 206 657 56 2 2 33.59213 1 1494.5 59.1 6.8 0 111.5 599 845 19 396 41 2 3 27.52136 2 1444.6 89.1 6.8 0 280.1 1073 486 168 569 48 2 1 32.99127 1 445.2 14.4 5 0 102.8 862 160 108 493 48 2 1 21.83513 1 1849.8 80.6 13.8 3.2 549.1 4291 661 274 344 32 2 2 20.15787 2 1678.2 54.3 12.9 1.5 147.3 1668 666 120 620 38 2 1 46.73763 2 1390.4 55.7 10.8 0 195.1 2809 482 53 277 52 2 1 33.29617 2 1749.9 81.3 12.1 0 226.5 2373 1816 105 464 40 2 1 24.01031 3 742.3 36.5 5.9 2.1 133.9 1850 309 159 542 44 2 1 23.07159 3 1148.5 50.3 7.1 0.1 139.2 1352 455 83 824 70 2 1 22.4821 1 1730.6 72.9 14.4 0.2 363.1 2315 1196 425 602 55 2 3 29.03568 3 1162.5 54 5.6 0.2 175.2 1417 451 99 670 48 2 1 20.21771 1 1738.9 63.5 12.2 0.5 205.9 4504 294 159 569 38 2 2 20.71761 3 1432.1 58.5 6.3 0.2 131.9 998 699 111 443 49 2 1 20.40345 1 3098.9 106.2 25.2 1.2 447.6 4430 632 316 399 36 2 2 32.95942 2 2342.3 95.8 19.2 1.7 389.4 3201 1574 105 489 64 2 1 21.50106 1 2319.9 97.6 22.3 0 155.3 3686 523 317 491 49 2 2 23.67945 2 1292.8 43.1 10.6 11 180.7 2131 227 372 1443 49 2 3 22.72159 1 784.4 40.6 4.9 3 97.4 852 311 116 602 43 2 1 22.91464 2 2038.5 80.7 17.1 0 232.3 2781 757 229 748 33 2 1 23.93777 2 1366.8 55.9 6.2 0 196 1151 498 51 602 38 2 1 26.09433 1 1550 66.8 12.1 0 253.2 3970 390 286 502 36 2 1 19.76645 2 1240.7 50.9 6.9 0.3 116 808 349 110 527 33 2 2 21.67339 2 2814.6 111.2 16.8 0 399.3 843 1616 143 470 47 2 2 20.81303 1 1612.5 45.5 9 15 149.9 2537 295 1212 566 53 2 1 40.68923 1 1576.3 54.8 13.5 0.1 308.9 2205 824 174 491 41 2 1 29.14229 1 1197.7 54.5 4.9 0 135.6 587 215 86 663 36 2 1 21.07775 1 2045.3 84.8 13.2 0.7 271.9 3591 1178 132 526 32 2 2 35.97525 2 3328.4 163.3 20 4.1 425.5 3434 2167 58 556 57 2 2 26.94287 1 2513.3 98.9 10.6 0 428.1 2869 741 77 394 42 2 1 21.67837 1 1737.4 62.1 16.3 0.2 211.7 2515 1340 237 737 37 2 3 27.26545 1 1034.4 34.5 8.9 0 118.5 807 141 41 573 52 2 1 32.67183 1 2083.9 93.1 8.8 0 328.1 766 604 103 713 45 2 3 28.72542 2 1481.8 75.3 10.4 0.2 336.9 720 701 193 777 42 2 1 20.76896 3 1051.2 44 10.9 0.2 165.5 516 730 153 437 42 2 1 21.20646 1 1730.1 58.3 16.6 4.5 196.1 3785 642 1391 609 41 2 3 20.71761 3 1102.8 56.6 5.3 0 329.8 1436 522 89 481 41 2 1 26.31172 1 1496.7 64.6 5.9 1 239.8 613 509 84 471 26 2 3 20.5412 1 1987.2 76.6 9.8 0 156.1 1460 322 36 296 70 2 1 20.16133 3 2017.2 136 7.6 0 195.8 2251 1404 494 499 44 2 1 26.36754 1 1525.6 85.4 7.9 0.1 179.4 2029 898 78 559 46 2 1 28.40199 3 1342.2 69.7 5.9 1 215.4 8046 453 102 701 22 2 1 50.40333 3 1511.7 64.4 10.2 0 190.3 1074 399 50 332 46 2 3 21.67837 3 1570.1 74.1 13.7 0.9 145.7 3556 577 211 388 32 2 1 20.05597 1 2703.4 120.6 11.4 0.1 284.3 1218 978 159 879 27 2 2 23.87631 3 1200.6 61.5 8.7 1.5 208.7 2199 481 89 323 52 2 1 37.11131 3 1891.6 73.8 17.6 0 226 5810 840 108 625 42 2 1 36.59729 1 1434.9 59.3 11.2 0 281.1 1214 1119 188 614 34 2 1 28.5795 3 2118.1 93 20.1 0 170 2215 1450 75 525 36 2 1 40.29532 2 1414.6 51.2 13.7 0 135.8 1678 1307 14 432 59 2 2 24.80399 1 2192.3 78.7 14.2 0 173.5 2579 1026 165 734 75 2 1 36.47368 2 1380.6 54.5 13.5 0.1 201.6 925 707 143 364 43 2 1 45.85808 1 1626.3 72.2 7.9 0 157.5 404 1050 241 387 56 1 2 30.48244 3 2210.7 113.1 10.5 6.1 340.1 2008 638 97 709 48 2 2 19.70388 3 1600.7 77.7 11.2 7.2 180.1 2469 538 76 561 34 2 3 21.96384 3 1076.2 52.7 6.1 0 78.3 755 417 169 418 37 2 1 23.34593 2 2094.5 78.9 17.3 1 193.4 1718 1052 222 413 41 2 2 31.82158 2 1823 74.8 12.1 1.3 196.9 2133 728 82 506 74 2 1 23.34593 1 1512.1 73.8 8.7 5.7 182.8 1167 1169 324 628 73 2 1 21.01134 3 840.6 34.3 8.2 0.1 81.1 619 79 146 578 53 2 3 19.78098 2 1996.1 98.8 9.2 0 436.8 908 1478 126 486 74 1 1 21.13641 3 2171.6 76.6 20.4 0 176.3 3690 1113 293 875 77 2 2 24.32719 1 1481.4 55 11.2 0 191.7 3425 859 183 817 39 2 1 21.17809 1 1829.2 79 15.6 0 178.4 2787 1210 170 647 29 2 1 18.6003 2 1041.6 45.4 6 3 139.5 675 403 129 820 37 2 1 44.91065 2 2010.4 101.2 16 0.1 362.4 2142 601 129 557 47 2 1 23.96418 3 2120.8 77.4 17 8.4 185.9 2299 1529 92 520 64 2 1 21.20646 3 1008.4 35.4 5.6 14 37.7 544 30 44 521 36 2 2 42.88865 3 798.2 30.6 7.9 2.4 46.3 604 378 51 498 42 2 2 20.41723 3 3099.2 134.9 19 0.8 469.3 6558 816 103 436 64 2 2 25.65988 2 2055.7 114.4 13 0 248.4 2661 854 101 291 38 2 2 20.70294 1 2585.3 129.8 21.1 4 429.5 7362 964 372 293 39 2 1 28.40151 2 1906.5 86.4 10.4 15.5 265.9 2583 632 78 600 40 2 1 31.24219 1 3014.9 165.7 14.4 0 900.7 1028 3061 0 254 29 2 1 37.93996 1 1631 55.6 13.8 0.5 189.5 3435 1104 84 644 71 2 2 24.98825 3 1399.5 66.5 9.6 8 260 1527 822 161 636 45 2 1 23.43164 1 2319 122.1 13.4 0.1 305.7 2047 1125 331 684 63 2 1 18.92094 3 1655.9 70.8 15.1 0.1 177.3 2897 505 366 535 46 2 2 24.26126 2 1422.8 58.3 7.8 7.1 206.3 1987 608 990 584 75 2 1 21.67837 1 2511.5 92.3 36.8 0.6 228.3 4271 916 1010 473 46 2 1 35.19069 2 740.6 38.5 5.3 0 113.9 868 106 236 647 44 2 2 22.54403 2 1292.6 49.4 10.4 1.2 186.5 578 319 175 880 24 2 1 31.99715 3 3021.9 171 11.4 0.1 466.3 953 1176 67 376 32 2 1 22.51215 1 1918.4 63.1 16.1 5 202.2 1048 991 129 864 66 2 1 22.64384 3 2086.6 72.3 16 0 112.8 1439 476 317 589 43 2 1 26.34755 2 3449.7 172.8 20.5 1.4 381.3 3324 1558 168 510 73 2 2 24.94123 1 1186.4 46.1 10.5 1.5 119.7 921 668 613 770 54 2 1 25.75009 1 1724.7 75.1 18.2 0 173.3 1192 657 274 543 44 2 3 29.97738 3 1877.4 92.2 7.7 0.2 211.6 1665 937 94 791 55 2 2 22.87713 3 2272.6 94.5 10.9 14.2 269.2 3610 1825 122 537 70 2 3 23.82703 3 1514.4 51.7 14.2 7 97.5 3317 766 232 516 32 2 2 25.45726 1 2170.3 95.1 15.2 0.2 175.2 3313 1250 167 466 33 1 1 23.26895 2 2271.1 114.6 10.4 0 574.2 1270 544 32 194 49 2 2 22.50636 3 1469.9 50.4 12.1 0.7 118.8 1915 594 128 759 69 2 2 44.20619 3 2332.2 109.6 19.7 0.1 286.7 4013 1485 151 823 38 2 1 20.71735 2 1619.3 83.7 8.4 0.5 310.1 902 302 206 426 34 2 3 34.08181 3 1148.7 41.7 9.8 1 173.4 2247 682 75 403 49 2 1 20.08955 1 2512 64.9 30.2 0.6 168.5 4832 793 447 516 40 2 3 18.34323 2 833 38.8 5.5 0 145.3 577 444 339 560 41 2 2 28.04696 3 1808.4 61.5 10.5 17 176.1 1884 641 89 746 62 2 2 29.84944 3 2115.4 84.1 23.9 0 189.5 3172 658 39 368 28 2 1 20.125 2 1600.9 68 14.2 0.2 171.2 3102 453 88 792 78 2 1 41.68569 2 647.7 30.9 3.7 0 87.5 1186 466 114 719 67 2 1 30.73092 1 849.2 25.4 10.9 0 91.7 1237 285 66 995 51 2 1 24.90822 2 2166.9 105.8 15.6 0 349.1 4098 909 407 725 29 2 3 26.68738 2 2476.2 121.1 14.3 0 263.5 2889 1529 105 366 36 2 3 25.7393 3 1959.3 112.4 6.7 0.5 326.7 1097 966 140 1102 43 2 2 18.57692 3 1695.3 62.4 17.7 0 147.3 570 747 150 800 55 2 2 25.42584 2 2307.8 111 18.4 3.4 487.8 2627 1627 95 854 54 2 1 24.95499 1 1392.2 47.8 12.9 0 87.5 849 962 74 1517 32 2 1 39.56196 2 3511.1 114.7 13.9 0.2 444.7 2174 1814 202 649 65 2 1 26.75958 3 1276 60.5 12 3.5 87.3 1456 443 133 710 41 1 3 41.64947 1 2685.1 133.1 11.1 15 432.4 3728 587 63 1193 60 2 2 40.69531 3 1327 64.8 9.3 0.1 341 1987 670 22 581 73 2 2 25.84728 2 853.1 29.8 6.3 10 160.5 1022 125 151 721 71 2 1 21.81089 1 1215.8 43.8 12.3 5 110.8 2079 597 473 946 47 2 1 37.27761 3 1927.6 92.5 10.7 0 359.1 406 806 58 794 35 2 2 29.58546 2 2466.9 112.6 9.6 0.1 331.9 621 579 87 494 34 2 3 21.32906 1 3103.7 124.7 18.1 8.3 431 2652 1098 113 796 41 2 1 34.61493 3 2046.9 103 13.1 0 334.2 1745 445 117 738 33 2 2 18.57692 1 1835.9 74.1 23 0.7 184.2 2121 426 155 444 73 2 3 20.71119 2 1678.5 82.3 6.3 14.1 249.5 1078 416 41 669 67 2 2 26.94287 1 1049.2 44.6 9.6 0 247.2 2672 294 73 836 66 2 1 33.10759 2 1762.1 72.9 16.5 0 240.3 4935 422 113 986 44 2 3 23.27717 2 3183.1 119.4 6.9 35 378.8 1118 1257 100 926 36 2 2 24.74345 2 2838.8 88.5 24 4.5 252.4 9642 634 265 986 48 2 2 24.61465 2 2021.1 72.2 16.6 9 299.1 1392 1027 144 752 46 2 2 25.89669 3 2263.6 98.2 19.4 2.6 306.5 2572 1261 164 216 45 2 1 23.82703 1 1841.1 84.2 14.1 2.2 257.7 1665 465 80 328 49 2 1 24.26126 1 1125.6 44.8 11.9 4 150.5 6943 520 300 502 31 2 2 23.45255 1 2729.6 144.4 13.2 2.2 381.8 741 644 121 684 45 2 1 26.50808 1 1627 77.4 9.9 0.2 195.6 1242 554 233 826 Therese Stukel Dartmouth Hitchcock Medical Center One Medical Center Dr. Lebanon, NH 03756 e-mail: stukel@dartmouth.edu